The study of the effects of ultrasound on normal arterial wall and ateriosclerotic wall was started as early as in 1965. Various researches have proved the remarkable function of ultrasound in thrombolysis and ablation of arthromatous plague in peripheral arteries in vivo or in-vitro. Ultrasound has been broadly used in treatment of decalcification of the bicuspid and aortic valves and in the ablation of plaques in the carotid vessels. In recent years, several studies have shown that ultrasound is quite effective to ablate newly formed intra-arterial thrombi.
The Acolysis system was designed and developed based on this principle. Unlike invasive thrombolytic therapy for acute myocardial infarction, it causes no complications and averts re-operations. Hortptt held that this device could be used in patients with acute myocardial infarction for arterial embolic obstruction and patients who have failed in the conventional thrombolysis or have contraindications as well. The therapeutic effects of the Acolysis probe on the peripheral emboli and bypass post-operational emboli lies in the length and the elasticity of the catheter. The simplicity of the operation, no requirements of accurate location and time restriction all contribute to the clinical application of this device.
Ultrasound device for intravascular thrombolysis has been developed successfully and manufactured in the United States. Its basic component is a solid metal ultrasonic guiding catheter of 140cm in length with a polywired elastic distal sector, connecting with a cuspidal tip of 1.6mm in diameter. The probe can transmit ultrasound effectively while maintaining its natural elasticity. The device fits into a 7F guiding catheter over a 0.014-in guidewire. The principal part of the device consists of the integrated circuit elements controlled by a portable complex computer. The design of the software system guarantees the resonance and constant output of energy with the concomitant load change in the process of operation. The applied basal frequency of ultrasound is 45KHz and the arc amplitude of the catheter is 50um.
sclerotic plagues and
thrombi which guiding
catheter cannot pass
through?
and thrombi?
cancer?
frequency high-energy ultrasound
energy ultrasound thrombolysis
technology
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